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How mechanical force shapes the sweat glands?

Life science seminar

21. November
14.00 – 15.30 Uhr / 2 p.m. - 3:30 p.m.

CMMC and Center for Biochemistry

CMMC Seminar Room (Building 66)
Robert-Koch-Str. 21
50931 Köln


Catherine Pei-ju Lu - Department of Cell Biology, NYU Medical School, New York - US
Host: Catherin Niemann – CMMC and Center for Biochemistry

Sweat gland is the most abundant appendage in human skin and plays an essential role in thermoregulation and water balance. As a skin appendage derived from epidermal progenitors during development, it forms a straight duct first and the tip of the duct then differentiate into a coiled secretory gland. To date, the molecular mechanisms involving in the ductal v.s. glandular morphogenesis has not been elucidated. Here, we mapped the mechanical complexity of sweat gland microenvironment using atomic force microscopy and single-cell sequencing, as well as recapitulated tissue architectural intricacy using an ex vivo bioengineering platform and in vivo mouse models. We demonstrated that there is a coupling pattern between mechanical force gradient and spatial Wnt signaling that specifies the cell fates of ductal and glandular cells during morphogenesis. Our findings not only provide an advanced understanding of the glandular development, but also directly impact on spatial-temporal design of the glandular regeneration.
Overview of life science seminars at the University of Cologne: www.life-science-vortraege.uni-koeln.de.